Inhibition of Geranylgeranyl Diphosphate Synthesis in in Vitro Systems
نویسندگان
چکیده
The incorporation of [14C]mevalonate and [“Clisopentenyl diphosphate into geranylgeranyl diphosphate was investigated in in oitro systems from Cucurbita pepo (pumpkin) endosperm and from Auena sativa etioplasts. Mevalonate incorporation was effectively inhibited in the pumpkin system by geranylgeranyl diphosphate and geranylgeranyl monophosphate but less effectively by phytyl diphosphate or inorganic diphosphate. Membrane lipids, geranyllinalool, or lecithin enhanced mevalonate incorporation in the Cucurbita system. Incorporation of isopentenyl diphosphate was also enhanced by lecithin and inhibited by geranylgeranyl diphosphate in the Cucurbita system. NO lipid enhancement was found in the Auena system; inhibition by GGPP required a much higher GGPP concentration than in the Cucurbita system.
منابع مشابه
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